Prof. Paul Vouros | NU Chemistry&Chemical Biology

Faculty Profile

Dr. Paul Vouros

Professor

215 Hurtig Hall
tel: 617.373.2840
fax: 617.373.8795
email: p.vouros@neu.edu

Analytical Chemistry

Education
1965 Ph.D., Massachusetts Institute of Technology
1961 B.A., Wesleyan University

Research Interests

Mass spectrometry and its applications to bio-organic analysis is the central focus of the research in Prof. Vouros' group. Their efforts involve the investigation of both fundamental and applied problems. Prof. Vouros has established a strong reputation for the development of techniques that involve the interfacing of a separation methods - gas chromatography, liquid chromatography, and capillary zone electrophoresis - with mass spectrometry. Optimization of these sample delivery systems has enabled them to advance the state of the art for trace level analysis of biological samples.

As a result of the commitment of the program to the solution of real life analytical problems, a number of active collaborations with clinicians and other biomedical colleagues both in the Boston area and nationally have been initiated. Some of the main areas of investigation include the following: analysis of DNA adducts through development of techniques for the trace level detection and characterization of modified nucleosides or nucleotides as a result of the covalent binding of carcinogens with DNA; applying LC-MS and GC-MS to study the metabolic pathways of vitamin D; characterization and sequencing of oligosaccharides by ion trap MS; and studies in capillary electrochromatography (CEC) and CEC-MS of complex, biologically significant mixtures.

Selected Publications

Andrews, Christine L.; Li, Feng; Yang, Eric; Yu, Chung-Ping; Vouros, Paul. Incorporation of a nanosplitter interface into an LC-MS-RD system to facilitate drug metabolism studies. Journal of Mass Spectrometry (2006), 41(1), 43-49.

Levin, Daren S.; Vouros, Paul; Miller, Raanan A.; Nazarov, Erkinjon G.; Morris, James C. Characterization of gas-phase molecular interactions on differential mobility ion behavior utilizing an electrospray ionization-differential mobility-mass spectrometer system. Analytical Chemistry (2006), 78(1), 96-106.

Brown, Alex J.; Ritter, Cynthia S.; Weiskopf, A. S.; Vouros, P.; Sasso, Gino J.; Uskokovic, Milan R.; Wang, Guochun; Reddy, G. Satyanarayana. Isolation and identification of 1? -hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion. Journal of Cellular Biochemistry (2005), 96(3), 569-578.