Education
1968 Ph.D. , New York University
1966 M.S., New York University
1962 B.S., City College of New York

Research Interests
Professor Krull’s research interests are in several areas of analytical biochemistry/biotechnology, especially methods for the analysis and detection of biopolymers and largely emphasize the use of separations methods including HPLC, HPCE, mass spectrometry, and capillary electrochromatography. He has developed, validated, and applied such separation methods for numerous proteins, antibodies, and peptides, of natural and/or recombinant derivation, especially those of commercial interest and medicinal applications. These methods have often been developed and applied in collaboration with industrial colleagues.

At present there are two major areas of research activity.  These include efforts to develop: (1) multidimensional HPLC-MS analytical methods for proteins/peptides and proteomics; and (2) planar electrochromatography (PEC) of peptides and proteins, in 1-dimension or 2-dimensions (PEC/TLC) for peptidomics and proteomics, then interfaced with various MS detection approaches. Much of this work has been undertaken together with biotechnology, pharmaceutical and/or instrumentation firms, often using specialized instrumentation available therein.

	pIs of Ab D2E7 isoforms calculated by an internal pI standard calibration curve

Selected Publications

V. Panchagnula, A. Mikulskis, L. Song, Y. Wang, T. Knubovets, E. Scrivener, E. Golenko, I.S. Krull, M. Schulz, H.E. Hauck, and W. F. Patton. Phosphopeptide analysis by direct coupling two-dimensional planar electrochromatography/thin-layer chromtaography with matrix-assisted laser desorption time-of-flight mass spectrometry. J. Chromatogr., A (2007), 1155, 112.

Millea, K.M.; Krull, I.S.; Chakraborty, A.B.; Gebler, J.C.; Berger, S.J. Comparative profiling of human saliva by intact protein LC/ESI-TOF mass spectrometry. Biochim. Biophys. Acta (2007), 1774(7), 897-906.

Millea, Kevin M.; Krull, Ira S.; Cohen, Steven A.; Gebler, John C.; Berger, Scott J.   Integration of Multidimensional Chromatographic Protein Separations with a Combined "Top-Down" and "Bottom-Up" Proteomic Strategy.  Journal of Proteome Research  (2006),  5(1),  135-146.