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[ Faculty
] [ Adjunct Faculty
] [ Lecturers ] [ Professor Emeritus
] [ Administrator Staff ] [ Teaching and Technical Staff
] [ Research Associates ] [ Graduate Students ]
Dr. Paul
Vouros
Analytical Chemistry
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Education
1965 Ph.D., Massachusetts Institute of Technology
1961 B.A., Wesleyan University
Research Interests
Mass spectrometry and its applications to bio-organic analysis is
the central focus of the research in the group of Prof. Vouros.
Their efforts involve the investigation of both fundamental and
applied problems. Prof. Vouros has established a strong reputation
for the development of techniques that involve the interfacing of a
separation methods - gas chromatography, liquid chromatography, and
capillary zone electrophoresis - with mass spectrometry.
Optimization of these sample delivery systems has enabled them to
advance the state of the art for trace level analysis of biological
samples.
As a result of the commitment of the program to the solution of real
life analytical problems, a number of active collaborations with
clinicians and other biomedical colleagues both in the Boston area
and nationally have been initiated. Some of the main areas of
investigation include the following: analysis of DNA adducts through
development of techniques for the trace level detection and
characterization of modified nucleosides or nucleotides as a result
of the covalent binding of carcinogens with DNA; applying LC-MS and
GC-MS to study the metabolic pathways of vitamin D; characterization
and sequencing of oligosaccharides by ion trap MS; and studies in
capillary electrochromatography (CEC) and CEC-MS of complex,
biologically significant mixtures.
Selected Publications
"Interfacing of CE on a PVP Matrix to Ion Trap Mass
Spectrometry: Analysis of Isomeric and Structurally Related (N-Acetylamino)
fluorene - Modified Oligonucleotides," Harsh, A.; Vouros, P. Anal.
Chem. 1998, 70, 3021
"Analysis of DNA Adducts by Capillary Methods Coupled to Mass
Spectrometry: A Perspective," Appruzzese, W.; Vouros, P. J.
Chromatogr. 1998, A 794, 97-108
"Advances in Capillary Electrophoresis - Mass Spectrometry:
Recent Developments in Interfaces and Applications," Ding,
J.-M.; Vouros P. Anal. Chem. 1999,171 378A-385A |
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